Combination of structure-performance and shape-performance relationships for better biphasic release in electrospun Janus fibers

In nature, the combination of composition, structure, and shape determines matter's functional performance to a large extent. Inspired by which, two electrospun Janus nanofiber formulations were created using side-by-side electrospinning in this work. Tamoxifen citrate (TAM) was used as model drug ethyl cellulose (EC) polyvinylpyrrolidone K60 (PVP) polymer carrier matrices. The fibers have linear cylindrical morphologies distinct structures scanning electron microscopy. One side took round shape, while other crescent-shaped. present both matrices form amorphous solid dispersions, owing strong intermolecular interactions between polymer. vitro dissolution tests demonstrated that sets could provide biphasic release due difference solubility PVP EC. different TAM-EC TAM-PVP structure resulted considerable variation profiles. with crescent gave more rapid burst first phase release, slower sustained second phase. This work thus reports new strategy for systematically developing advanced nanomaterials based on shape- structure-performance relationships.